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Gynecomastia in a Patient with Partial Androgen Insensitivity Syndrome

Sourya Acharya1, Nipun Bawiskar, Samarth Shukla, Sunil Kumar, Raju Shinde

Male breast enlargement as a result of increase in the amount of glandular breast tissue is referred to as Gynecomastia. It may be due to multitude of causes like drugs, endocrine diseases, physiological enlargement or systemic diseases. Androgen Insensitivity Syndrome (AIS) is one such condition which occurs due to a mutation in the androgen receptor gene. It is a disorder of male sexual differentiation and may presents as gynecomastia in a patient with a karyotype of 46 XY. Phenotypically it can be partial, complete or mild and can present among both men and women as infertility with ambiguous genitalia. In this case report we present a male with gynecomastia later identified as partial androgen insensitivity syndrome.