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FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF CANDESARTAN CILEXETIL USING NATURAL AND SYNTHETIC SUPERDISINTEGRANTS

Basawaraj S.Patil, N.G.Raghavendra Rao

In the present work attempts were made to prepare fast dissolving tablets (FDT) of candesartan cilexetil by direct compression method with a view to enhance patient compliance. The synthetic and natural superdisintegrants used in this study were croscarmellose sodium, and plantago ovata mucilage. Tablets having superdisintegrant at different concentration (2.5, 5, 7.5 and 10 mg) level were prepared. The prepared batches of tablets were evaluated for uniformity of weight, thickness, hardness, friability, drug content, wetting time, in vitro dispersion time and in vitro dissolution study. Swelling index was also investigated with an aim to compare the swelling property of plantago ovata mucilage with synthetic superdisintegrant. Compare to croscarmellose sodium, plantago ovata mucilage showed the highest swelling index. Hence, the present work revealed that this natural superdisintegrant, plantago ovata mucilage showed better disintegrating property than the most widely used synthetic superdisintegrants in the formulation of fast dissolving tablets