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Extraovarian Granulosa Cell Tumor with Call-Exner Body-like Microfollicular Arising from Ileum: A Case Report and Review of Literature

Zeng Rong, Huang Wei, Hu Peng, Guo Fang, Zhang Huifeng*

Background: Granulosa Cell Tumors (GCTs) arising outside the ovary are extremely rare. Only 7 cases were reported previously. The clinical characteristics, surgery, therapy, prognosis, pathology and origin are unknown. This is the first case reported of extra ovarian GCT arising from ileum.

Case presentation: A 44-year-old nulliparous Chinese female presented with weight loss, anorexia and hiccups for 3 months. Surgeries revealed a 8 × 7 × 6 cm, solid mass arising from distal ileum, separating from the adnexa and uterus of normal appearance. Postoperative pathology confirmed the primary extra ovarian GCT of ileum. Only one month of disease-free after four cycles of postoperative chemotherapy was remained when metastatic tumor developed in liver.

Conclusion: GCTs can arise from tissues other than ovary, may be with poor prognosis, and origin from mesenchymal tissues of embryologic genital ridge.