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Experimental Investigation of Acute and Delayed Renal Effect of Exogenous Thyroxine

Sergiy Dolomatov, Radoslaw Muszkieta and Walery Zukow

Introduction: Normally, thyroid hormones are important regulators of metabolic processes in mammals.

Aim: To study the renal function of rats in a single dose of thyroxine, as well as analysis of remote renal effects of experimental hyperthyroidism.

Materials and methods: The study used inbred male rats massing 200-250 g, the experimental hyperthyroidism caused a 10-day daily intragastric sodium salt of thyroxine, suspended in 1% of starch gel. Thyroxine produced by Berlin Chemie (Germany) was administered to 20 micrograms per 100 g of body mass. The function of the kidneys of rats were studied under conditions of induced diuresis induced by water stress, 24 h after the single purpose of thyroxine, 24 h after the completion of the 10-day administration of the hormone, as well as 14 days after completion of the 10-day administration of the hormone. A control group of animals using appropriate age and body mass euthyroid male rats treated with the gel containing no hormone.

Results: Studies have shown that under conditions of water stress within 24 h after a single injection of thyroxine (Table 1) there is no significant variation in urine output, expressed in absolute values per 100 g of body mass of the animal, as well as the ratio of urine to the volume fluids (relative diuresis).

Conclusions: It is shown that the duration of the appointment in rats’ thyroxine promotes the further strengthening potassuresis. The magnitude of the glomerular filtration rate is reduced, and the rates of sodium excreted by the kidneys are quite moderate.

1) Found that 14 days after cessation of thyroxine to rats is not observed significant variations in the values of glomerular filtration rate and potassium excretion by the kidneys, however, the rate of sodium excreted by the kidneys clearly exceed the benchmarks.

2) Found that a single injection of thyroxine to rats has no effect on the magnitude of diuresis, but induces a distinct increase in sodium excretion by the kidneys, stimulates potassuresis and lowers the glomerular filtration rate.