select ad.sno,ad.journal,ad.title,ad.author_names,ad.abstract,ad.abstractlink,j.j_name,vi.* from articles_data ad left join journals j on j.journal=ad.journal left join vol_issues vi on vi.issue_id_en=ad.issue_id where ad.sno_en='54549' and ad.lang_id='10' and j.lang_id='10' and vi.lang_id='10' Evaluation of a Multimarker Panel in Chronic Heart Failure: | 54549
மருத்துவ வேதியியல் மற்றும் ஆய்வக மருத்துவ இதழ்

மருத்துவ வேதியியல் மற்றும் ஆய்வக மருத்துவ இதழ்
திறந்த அணுகல்

சுருக்கம்

Evaluation of a Multimarker Panel in Chronic Heart Failure: A 10 Years Follow-Up

Susanne Bauer, Christina Strack, Ute Hubauer, Ekrem Ücer, Stefan Wallner, Andreas Luchner, Lars Maier, Carsten Jungbauer

Background: Chronic heart failure is a complex disease associated with various pathophysiological and biochemical disorders. We assessed the 10 years prognostic role of a multimarker panel of markers for myocyte stress (GDF-15), extra-cellular matrix remodeling (Galectin-3, mimecan, TIMP-1), inflammation (Galectin-3), myocyte injury (hs-TnT) and angiogenesis (endostatin, IBP-4, IGF-BP-7, sFlt-1 and PLGF) head-to-head with the biochemical gold-standard NT-proBNP.
Methods: Blood samplesfrom 149 patients with heart failure were analysed. After 10 years of follow-up (median follow-up 104 months, IQR 43-117), data regarding rehospitalisation for chronic heart failure and all-cause-mortality were acquired.
Results: Regarding Kaplan Meier analysis, all markers, dichotomized according to you denindex, were significant predictors for all-cause-mortality (each p<0.05) and for the combined end point of all-cause-mortality and rehospitalisation (each p<0,05). Including all markers in Cox Regression analysis, NT-pro-BNP, hs-TnT and IGF-BP7 were independent predictors for both end points (each p<0,05). Patients in whom all three markers were elevated had a significant worse long-time-prognosis than patients without elevated markers (risk of all-cause-mortality 90,5% vs. 25%, risk of all-cause-mortality or rehospitalisation 97,6% vs. 43,7%). In a Cox regression model with clinical relevant parameters (ejection fraction<30%, age, serum creatinine, gender) and the multimarker panel (hs-TnT, NT-pro-BNP, IGF-BP7), all biomarkers remained independent significant predictors for both end points beside ejection fraction<30% and male gender (each p<0.05).
Conclusion: In a 10-years-follow-up, a combination of three biomarkers with different pathophysiological background (NT-pro-BNP, hs-TnT and IGF-BP7) increased the prognostic value and identified patients with a high risk of mortality and rehospitalisation. Especially IGF-BP7 seems to play an important role regarding prognostication in heart failure.

மறுப்பு: இந்த சுருக்கமானது செயற்கை நுண்ணறிவு கருவிகளைப் பயன்படுத்தி மொழிபெயர்க்கப்பட்டது மற்றும் இன்னும் மதிப்பாய்வு செய்யப்படவில்லை அல்லது சரிபார்க்கப்படவில்லை.
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