ஜர்னல் ஆஃப் புரோட்டியோமிக்ஸ் & பயோ இன்ஃபர்மேடிக்ஸ்
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In Silico Structure Prediction, Analysis and Energy Calculation of Retinol Binding Protein7 (RBP7) in Coturnix coturnix japonica (japanese quail)

Aishwarya Tiwari, Vijay Laxmi Saxena and Mithun Kumar Patel

The biologically dynamic natural occurring retinoid (retinol and its metabolites, vitamin A) is intermediated by extracellular, intracellular, and nuclear proteins in Coturnix japonica or japenese quail. Retinoids mainly transmit by two medium such as Plasma retinoid binding protein (RBP) and Epididymal retinoic acid binding protein (ERABP) carries retinoid in body fluid while cellular retinol binding proteins (CRBPs) and cellular retinoic acid binding proteins(CRABPs) carry retinoids within cells. Accurate description of amino acids of RBP7 is very important to consider when prediction of structure and calculation of energy take place. The aim of the study is prediction the structure of RBP7 in Coturnix japonica using Bioinformatics tools and software approach. Ramachandran plot of the φ, ψ values for the amino acids in a RBP7 protein. Using this computational approach the total energy of RBP7 in Coturnix japonica is 1047.341 KJ/mol. And total minimum energy is 1026.898 KJ/mol in Cotunix japonica or japenese quail. It is also observed that repeating energy trends at each of the molecular, functional group, and atomic levels. Retinols and retinoic acid play essential characters in variation of gene expression and overall growth of embryo in Coturnix japonica. This makes RBP7 more significant in terms of expression of adipose tissues in Coturnix japonica (japenese quail) because RBP7 works as a novel adipose-specific gene.