ஜர்னல் ஆஃப் புரோட்டியோமிக்ஸ் & பயோ இன்ஃபர்மேடிக்ஸ்

ஜர்னல் ஆஃப் புரோட்டியோமிக்ஸ் & பயோ இன்ஃபர்மேடிக்ஸ்
திறந்த அணுகல்

ஐ.எஸ்.எஸ்.என்: 0974-276X

சுருக்கம்

In Silico Predictive Homology Modeling of PKHD-1 Protein: A Comparative Study among Three Different Species

Arunannamalai SB

Background: The PKHD-1 (Polycystic Kidney and Hepatic Disease-1) gene encodes a crucial protein vital for renal and hepatic functions. Mutations in PKHD-1 result in Autosomal Recessive Polycystic Kidney Disease (ARPKD), a severe disorder in early infancy. Despite its significance, the structural information on PKHD-1 remains limited, with few low-resolution structures accessible. Homology Modeling was employed to generate structural models of PKHD-1 proteins from three species: Homo sapiens (Human), Mus musculus (Mouse) and Canis lupus familiaris (Dog). Various bioinformatics tools were utilized for analysis and validation.

Results: Structural models of PKHD-1 proteins from different species were generated using Homology Modeling and advanced bioinformatics tools, including SWISS-Model, ProtParam, GOR4, Protein Structure Analysis (PROSA) Web, ExPasy QMEANDisCo and P2Rank. The primary structure, physicochemical properties and secondary structure of PKHD-1 proteins were analyzed and validated. Binding pockets critical for understanding functional roles and potential therapeutic interventions were predicted using the P2Rank tool.

Conclusion: This study provides comprehensive structural insights into PKHD-1 proteins across multiple species. Rigorous validation of homology models through Z-Score analysis and QMEANDisCo Global Score ensures their reliability and accuracy. The identification of binding pockets offers potential targets for therapeutic interventions. Comparative analysis of PKHD-1 protein structures enhances understanding of evolutionary relationships and lays the foundation for future comparative functional studies. This research significantly contributes to structural biology and biomedical research, serving as a valuable resource for researchers investigating PKHD-1 function, disease mechanisms and drug targeting strategies. The findings pave the way for exploring species-specific functions and adaptations of PKHD-1, fostering advancements in the understanding and treatment of ARPKD and related disorders.

மறுப்பு: இந்த சுருக்கமானது செயற்கை நுண்ணறிவு கருவிகளைப் பயன்படுத்தி மொழிபெயர்க்கப்பட்டது மற்றும் இன்னும் மதிப்பாய்வு செய்யப்படவில்லை அல்லது சரிபார்க்கப்படவில்லை.
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