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EFFECT OF ENHANCERS AND IONTOPHORESIS ON CAPTOPRIL PERMEABILITY THROUGH EXCISED PIG SKIN

Ashish Jain1, Satish Nayak, Vandana Soni

In vitro transdermal delivery of captopril across excised pig skin using various enhancers investigated. Permeation studies carried out at the modified franz diffusion cell. Steady state fluxes, permeability coefficients, diffusion coefficients, benefits and enhancement ratios by various enhancers were determined. Incorporation of various permeability enhancers like dimethyl sulfoxide, peppermint oil, menthol, oleic acid, sodium louryl sulphate, poly ethylene glycol with pure drug solution showed synergistic effect when combined with iontophoresis. Dimethyl sulfoxide was the most active enhancer, and when combined with iontophoresis it was possible to deliver 103.940 mmol/cm2 of drug at the end of 8 hours, it was 4.4 times enhancement as compare to delivery of drug without enhancers.