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DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF METOPROLOL TARTRATE

Chaitali Dhale, Suhas Joshi, Shubhangi Shete

ABSTRACTThe objective of present work was to develop an UV spectrophotometric method for determination of Metoprolol Tartrate in bulk and Tablet dosage form. In this method Dist water, Phosphate Bufffer 6.8 and 0.1 N HCl used as a solvent. In all the solvent Metoprolol Tartrate shows absorption maxima at 222 nm. The Beer’s law range for Distilled water, Phosphate buffer 6.8 and 0.1 N HCl was in 5-30 μg/ml. This method was validated as per International Conference on Harmonization (ICH) guidelines. Low values of %RSD for intra- and inter-day precision suggested reproducibility of the method. Satisfactory values of percent recovery indicated accuracy of the method. Sensitivity of the method was proved by low value of Limit of Detection and Limit of Quantitation. Regression analysis of the calibration data showed a good correlation coefficient. The method was found to be simple, accurate, precise and economical.