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COMPARATIVE STABILITY STUDY OF METRONIDAZOLE IN AQUEOUS AND NON AQUEOUS VEHICLE

Satish Nayak, D. C. Goupale, Atul Dubey and Vipin shukla

Metronidazole is commonly used for the treatment of Helicobacter pylori associated peptic ulcer. Though the Metronidazole is relatively stable with little degradation in aqueous phase but its stability is quite higher in non aqueous phase. The current article discusses about the improvement of stability of metronidazole in non aqueous vehicles which may be useful for the development of liquid formulations containing this drug. The stability study of the drug was carried out at different temperatures and relative humidity according to the ICH guidelines. It was found that the Metronidazole was about 3.7, 4.4, 4.8, 5.3 and 5.9 times more stable in 20%, 40%, 60%, 80% and 100 % v/v propylene glycol solution as compared to aqueous solution at 400C and 75% RH.