ஜர்னல் ஆஃப் நானோமெடிசின் & பயோதெரபியூடிக் டிஸ்கவரி
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Bio-inspired Nanotechnologies as Drug Delivery System

Ahmad U

Technological developments in healthcare have been at the center of focus during last decade. The rise of Nano therapeutic platforms has seen recent advancements in combating deadly diseases like cancer. A lot of research is already done on nanotechnology systems like liposomes, Nano emulsions, dendrimers and micelles, and recently carbon nanotubes and quantum dots have been in focus for their therapeutic and diagnostic capabilities. Most of these systems are utilized to improve the solubility and bioavailability profiles of certain drugs along with targeting capabilities to some extent. However, toxicological and environmental concerns of the nanomaterial used in these systems have raised alarm among researchers and thus forcing investigators for finding new gateways to delivery of drugs to target sites. During this decade there’s been a sharp rise in bio-inspired and biomimetic drug delivery systems. Bio-inspired platforms mimic the natural components inside the body making them more safe and effective in delivering drugs.

Since its introduction decades ago nanotechnology has delivered promising solutions in healthcare industry. Nanotechnology has been widely used for both diagnostic and therapeutic purposes. Platforms like liposomes, dendrimers, Nano emulsions, micelles, and carbon nanotubes have been effectively utilized for treatment of cancer. These systems also offer advantage of minimizing the drawbacks associated with the drugs like solubility, stability and bioavailability. Nanotechnology has touched all realms of life including food and cosmetic industry. The success is widely embraced in the scientific community offering newer applications day by day. However, some researchers have raised a genuine concern related to toxicity of nanomaterial inside body. Since nanoparticles are extremely small in size they reach deep inside tissues and cells. Investigators have concern regarding its elimination from the body. Some investigations reveal that inorganic nanomaterial get deposited deep into the tissues and cause serious side effects to human body. Use of organic and biodegradable substances in Nano formulation has minimized this problem to some extent. However a complete safe and reliable approach is a necessity for successful delivery of drugs. This is where bio-inspired delivery systems show its importance. It has been observed that imitating nature’s way of transporting substances and cells inside the body could help in enhancing the pharmacological activity and reducing the unavoidable side effects associated with drugs.

Advanced drug delivery system behaves like a supercomputer. It offers both ‘hardware’ and ‘software’ components that controls the handling and administration of drug and regulates the local or systemic release and also sense the microenvironment through which the drug has to pass in the route towards the action site. Bio-inspired drug delivery systems are designed familiar to biological molecules which are continuously transported inside the body. Biomimetic has been recently defined as an emerging field of science that includes the study of how Nature designs, processes and assembles/disassembles molecular building blocks to fabricate high performance soft materials and mineral-polymer composites, and then applies these designs and processes to engineer new molecules and materials with unique properties. Biological molecules like erythrocytes, bacterial ghosts and genetically engineered stem and dendritic cells have been widely used and accepted for drug delivery purposes. Their unique properties make them suitable for in-vivo investigations. For example, resealed erythrocytes have been widely exploited for delivery of nanoparticles. Drugs could be incorporated inside the core of RBCs or attached onto the surface for successful delivery of medicaments. Bacteria use fimbriae and flagella filaments to attach themselves to human mucosa. This unique property of bacteria could be exploited in muco adhesive drug delivery of nanoparticles. Similar inspirations have been drawn from Velcro-like hook-and-loop fasteners, Gecko-inspired (geometric-based) adhesives and mussel adhesive proteins for successful drug delivery.

Drugs delivered via bio-inspired mechanisms tend to remain inside the human body for longer duration and develop unique strategies to evade the host immune systems. Bacteria that are used for development of bio-inspired delivery systems are non-pathogenic and generally regarded as safe (GRAS). Some of them include Lactococcus lactis which is utilized for protein production and Streptococcus gordonii have ability to colonize mucosal surface in oral, nasal and vaginal cavity. Apart from producing cytokines and enzymes attenuated pathogenic bacteria have also been used to target tumors. Similarly investigators developed a Nano machine termed as ‘microbots’ which are basically bacteria which have been used to load nanoparticles for successful delivery at desired sites.