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Association Study of Single Nucleotide Polymorphisms in KDM3A and LOC203413 Genes with Male Infertility

Poongothai J, Jeeva SE and Manonmani S

A case-control study conducted on fertile and infertile men in Coimbatore population. The study, aimed to identify and associate the following two single nucleotide polymorphisms (SNPs) rs2030259 and rs5911500 in genes KDM3A (lysine (K)-specific demethylase 3A) and LOC203413.The SNPs were identified by restriction fragment length polymorphism (RFLP) technique in 17 normospermic individuals and in 13 infertile males (9 oligospermic and 4 azoospermic) and results were analysed using fisher’s exact test. Although the polymorphisms were found in both fertile and infertile men, no significant association is found for both 2 SNPs with infertility from the samples observed.