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ASSESSMENT OF THYROID HORMONES LEVEL IN PREMENOPAUSAL AND POSTMENOPAUSAL FEMALES

Tasnim Farasat, Ayesha Liaqat, Tahira Mughal

Thyroid dysfunction is the common endocrine disorder and females are more affected than males. The aim of this study was to assess the serum thyroid hormone level in premenopausal and postmenopausal females with thyroid dysfunction and observe the effect of thyroid dysfunction on body weight and menstrual regularity. Total 91 female subjects were included in the study. Serum thyroid hormone levels of TSH, FT3 and FT4 were assessed by ELISA technique. It was observed that serum TSH levels were significantly higher in premenopausal and postmenopausal hypothyroid females groups (P<0.01) as compared to the control group with normal thyroid function. Demographic characteristics and disease history of the subject were collected. In hyperthyroid premenopausal females serum TSH level was significantly lower than the control group (P<0.01). Serum FT3 level was significantly higher in hyperthyroid premenopausal and postmenopausal females as compared to control group (P<0.01). In this study, 80% of premenopausal hypothyroid females and 65% of hyperthyroid females complained about menstrual irregularities, this percentage is high as compared to control subjects, which is 20% (P<0.01). Inverse negative correlation was observed between TSH, T3, TSH, and T 4, whereas positive correlation was observed between T3 and T 4. Thyroid dysfunction can lead to menstrual irregularities