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Assessment of Screening Tests Used to Detect Toxoplasma gondii in Women in Sudan

Khalil Mohamed, Petr Kodym, Marek Maly and Intisar EL Rayah

Blood samples from 255 child bearing age women distributed into two villages named EL Nuba and EL Massoudia were collected according to their agreement and after obtaining their written consent form. Plasma separated from 255 blood samples were tested at delivery for Toxoplasma gondii antibodies using three different screening tests. These tests were Latex Agglutination Test (LAT), Complement Fixation Test (CFT), and ELISA IgG. Evaluation of the screening test was done for the three tests. The sensitivity of LAT, CFT, and ELISA IgG were 82.5%, 96.8%, and 98.9% respectively. The specificity of these tests was 91.2%, 94.1%, and 97.1% respectively. The Positive predictive value was 96.2%, 97.8%, and 98.9% respectively. The negative predictive value was 66%, 91.4% and 97.8%, respectively. The positive likelihood ratio was 9.35, 16.4, and 33.6 respectively. The negative likelihood ratio was 0.192, 0.0345, and 0.11 respectively. According to these evaluations a proposed protocol was drawn to detect infection in women.