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Administration of Cannabinol and Alcohol Altered the Liver Enzymes, Lipid Profile and Antioxidant Status of Male Wistar Rats

Akintayo C.O1, Olukiran O.S2*, Ayodele M.J3, Karga S.V3

Background: Cannabis and alcohol increasingly gain legalized status in many countries, the popularity and prevalence of use continues to grow.

Objective: This study was designed to investigate their effects on liver enzymes and lipid profile of rats.

Methods: Twenty five male rats were divided into 5 groups; group 1 was given distilled water; groups 2, 3, 4 and 5 rats were treated with 5% methanol, 25% alcohol, 10 mg/kg of cannabinol, 25% alcohol and 10 mg/kg of cannabinol p.o for 8 weeks respectively. Statistical analysis was done using the ANOVA.

Results: The serum concentrations of AST and ALT were significantly higher in groups 3, 4 and 5 when compared with groups 1 and 2. Groups 1 and 2 had LDL and HDL that were significantly lower than that of groups 3 and 4. Rats in group 5 had HDL that was significantly higher compared to group 1. The total cholesterol level of groups 3, 4 and 5 was significantly higher than that of groups 1 and 2. However, the rats in group 5 had total cholesterol level that was significantly lower when compared with groups 3 and 4. Groups 3, 4 and 5 had triglycerides concentration in the plasma that was significantly higher than that of groups 1 and 2. The photomicrographs of groups 3, 4 showed signs of dilated sinusoids when compared with groups 1 and 2.

Conclusion: It was concluded that the administration of alcohol and cannabinol altered the liver enzymes, lipid profile and antioxidant status of male rats.