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A Short Commentary on Understanding Inflammation Associated Ophth almic Pathologies: A Novel 3D Co-Culture Model of Monocyte-Myofibroblast Immunomodulation

Avi Petroff

The article titled “Understanding Inflammation-Associated Ophthalmic Pathologies: A Novel 3D Co-culture Model of Monocyte-Myofibroblast Immunomodulation” describes a simple 3D co-culture system that was used to model a human eye following glaucoma filtration surgery. Various specifications were implemented to the model to allow for a focused assessment on monocyte and myofibroblast immunomodulation of inflammatory cytokine signaling. However, the utility of such a model extends beyond the scope of the original paper, into areas of discovery such as pharmaceutical therapies and tissue-dependent models of inflammation and fibrosis. The original paper highlighted the importance of 3D and co-culture models for obtaining more comprehensive assessments of cellular responses to inflammatory stimuli, and thus the stress on these parameters should be maintained while other parameters may be modified for myriad scientific objectives.