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A Meta-analysis of the Association of COX-1 Gene rs3842788 and rs1330344 Polymorphism with Aspirin Resistance in Chinese

Wang Z, Chen Y, Hu S, Liu R, Yang W

The cyclooxygenase-1 (COX-1) gene rs3842788 variant (128G>A) and rs1330344 variant (1676G>A) have been associated with aspirin resistance in patients with cardiovascular disease. However, there is not enough evidence to demonstrate whether the A or G allele of COX-1 gene is indeed a genetic factor that can lead to aspirin resistance, with many of the studies coming to opposite conclusion. Here, we identified 10 articles on COX-1 in a literature search, and conducted a meta-analysis on the rs3842788 and rs1330344 genotype difference between aspirin resistance and aspirin sensitive patients. We found that there is no significant difference between cases and controls on GA+AA and GG genotypes of rs3842788 (OR, 1.22; 95% CI, 0.85-1.75; P, 0.29). The results provide additional evidence that rs3842788 of COX-1 gene maybe not a factor to cause aspirin resistance. However, we found that there is a significant difference between cases and controls on GA+GG and AA genotypes of rs1330344 (OR, 1.48; 95% CI, 1.15-1.90; P, 0.002). The results provide evidence that rs1330344 of COX-1 gene may be a factor to cause aspirin resistance. Therefore, more researches are needed to show the relationship between COX-1 gene and aspirin resistance.