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A Comparative Analysis of Saturated (SFAs) and Unsaturated (UNFAs) Fatty Acids in Chickens Oil and its Impact on Type 2 Diabetes Mellitus in Experimental Rats

Asaduzzaman M*, Lutfun Nahar, Manobendro Nath Ray, Md. Shahid Hossain, Md. Monjad Hossain and Noor Rahman Dastagir

Chicken meat is generally thought to be health friendly due to its favorable fatty acid composition leading to an antiatherogenic lipidemic status. Beneficial effect of the chicken oil on hyperglycemia has also been claimed through its effect on oxidative stress and insulin resistance. To further explore the potential benefits the effects of the oil from domestic and hybrid chicken for their fatty acid composition as well as for their effects on glycemic and lipidemic status in diabetic model rats were studied. There were significantly lower blood glucose value in DG and DDO groups at endpoint compared to baseline (mmol/l, mean ± SD, Baseline vs. Endpoint, 17.6 ± 0.98 vs. 16.5 ± 1.02; p= 0.001 and 18.4 ± 1.86 vs. 18.0 ± 1.0 ; p=0.001, for the DG and DHO groups at Endpoint compared to Baseline (mmol/l, mean ± SD, Baseline vs. Endpoint, 17.6 ± 0.98 vs. 16.5 ± 1.02; p= 0.001 and 18.9 ± 1.19 vs. 17.8 ± 1.84; p=0.001). for the DG and DDF groups at Endpoint compared to Baseline (mmol/l, mean ± SD, Baseline vs. Endpoint, 17.6 ± 0.98 vs. 16.5 ± 1.02; p= 0.001 and 19.2 ± 2.35 vs. 17.6 ± 2.19; p=0.001) and for the DG and DHF groups at Endpoint compared to Baseline (mmol/l, mean ± SD, Baseline vs. Endpoint, 17.6 ± 0.98 vs. 16.5 ± 1.02; p=0.001 and 19.9 ± 2.77 vs. 18.0 ±1.47; p=0.001). Chicken oil also showed hypolipidemic effects. 20% and 24% reduction of cholesterol level were observed for domestic and hybrid chickens oil treatment respectively in diabetic rats whereas 13% and 16% reduction were seen for domestic and hybrid chicken flesh. In case of glibenclemide, it was 33%. LDL level was reduced for domestic chicken oil, hybrid chicken oil, domestic chicken flesh, hybrid chicken flesh and glibenclemide at 19%, 20%, 16%, 18% and 22%. Whereas HDL level was increased significantly 33%, 37%, 26%, 32% and 44% respectively. The SGPT, SGOT and CRP were significantly decrease (p<0.05). Chickens oil has also effect of hepatoprotective activity.