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Neurobiology and Effectiveness of Antipsychotic Drugs in Resistant Obsessive-Compulsive Disorder: A Systematic Review

Forty to sixty percent of the patients with Obsessive Compulsive Disorder (OCD) is resistant to well conducted treatment with Selective Serotonin Reuptake Inhibitors (SSRIs) over period of 8 weeks. Data concerning the effectiveness of the addition of antipsychotics in this indication is controversial.