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Inbred Mouse Strain Susceptibility to Tuberculosis Infection Vary with Phenotype, the Dose of Infection, Obesity and Composition of the Intestinal Microbiome

Svetlana I. Kayukova, Andrew E. Donnikov, Irina V Bocharova, and Boris V Nikonenko

In this work, we conducted comparative studies of inbred mice with different sensitivity to tuberculosis infection, I/St susceptible, C57BL/6 resistant. Two other strains C3H.JK (H2j), C3H/HeDiSn (H2k) began to grow fat by 4-5 months of age and changed their susceptibility depending on the dose of infection. Also, they were made obese or not in dependence on the dose of infection.