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சுருக்கம்

Area Under Curve Method Development for Etodolac in Bulk and Tablet dosage form

Vaibhav G Bhamare, Renuka R Joshi, RD Amrutkar

A simple,precise, rapid and economical spectroscopic method has been developed for the determination of Etodolac in bulk and tablet dosage form. In methanol Etodolac shows absorbance maxima at 281nm. Method used was area under curve in which area incorporated in the wavelength range of 275nm-285nm.Etodolac obeys Beer’s law in concentration range 0-60µg/ml. Calibration curves were plotted at selected wavelengths and it was found to be linear (r2=0.9997) Linearity for detector response was observed in the concentration range of 5-30µg/ml. The recovery studies established accuracy of the proposed method and results validated according to ICH guideline. Precision and Accuracy studies were carried out and results were satisfactory. Robustness of the given method was studied by using two wavelength, 279nm and 283nm respectively. Results were found satisfactory and reproducible. The developed method was successfully applied to estimate the amount of Etodolac in pharmaceutical formulation.